The Role of Estrogen signaling in OSCC

Cancer is a collection of biological processes in the human body considered as one of the most
problematic diseases. Oral cancer is one of the worlds most advanced stages cancer with
convenient access, because its existence is not the patients chance of being alive. The mechanistic
and biological pathways study has helped better and faster prognosis and treatment of cancer. In
this study, OSCC data were analyzed with genetrail 2, the major rout of estrogen signaling pathway
in cancer effect we reached in the OSCC. The analysis identified seven genes associated with the
estrogen pathway in keg analyses. Sex hormone estrogen in men and women plays a fundamental
role, but with changes to its receptor, causes cancer. Considering studies in OSCC estrogen
receptor (ER) alpha is more important contact to miR-125a can be reduced apoptosis. Studies have
shown that only influencing of mir-125a associated with the estrogen receptor in OSCC has been
found. So After synthesis mir-125a in oral cancer mortality can be recovery and reach to new
drugs.